AOD-9604

AOD-9604 is a synthetic fragment corresponding to amino acids 177–191 of the human GH C-terminus with a stabilizing N-terminal tyrosine. This fragment retains the lipolytic properties attributed to full HGH but does not bind the GH receptor in a manner that triggers IGF-1 production or anabolic signaling. Research suggests activity via the beta-3 adrenergic receptor and hypothalamic regulation of fat metabolism.

Selective lipolysis: Stimulates fat breakdown in adipocytes without proliferative or anabolic effects seen with full HGH.

No IGF-1: Does not appear to raise IGF-1 in research subjects — important distinction for researchers studying selective fat loss.

Obesity models: Multiple animal studies show significant reduction in body fat percentage without muscle loss.

Cartilage: Some research suggests chondroprotective and cartilage regenerative effects via TGF-β modulation.

Metabolic syndrome: Improvements in lipid profiles and insulin sensitivity observed alongside fat reduction.