BPC-157

BPC-157 is a 15-amino-acid synthetic fragment derived from a region of human gastric juice proteins. Research models propose activity through upregulation of growth hormone receptor expression, activation of the FAK-paxillin pathway supporting cell migration, modulation of the nitric oxide system for vascular effects, interaction with dopaminergic and serotonergic systems, and direct cytoprotective effects on gastrointestinal mucosal cells.

GI integrity: Extensive rodent models show accelerated healing of gastric ulcers, intestinal anastomoses, and chemically-induced colitis.

Tendon-to-bone: Demonstrated superior healing of Achilles tendon transection in rat models vs untreated controls.

CNS: Studies in 6-OHDA dopamine-lesioned rats show partial recovery of motor function, suggesting dopaminergic modulation.

Bone healing: Fracture union acceleration observed in tibial fracture models alongside increased bone mineral density markers.

Angiogenesis: Upregulation of VEGF and nitric oxide pathways linked to observed vascular-supportive effects.