GHK-Cu

GHK-Cu is a naturally occurring tripeptide first isolated from human plasma in 1973. The copper(II) complex activates a remarkably broad range of biological responses including upregulation of collagen, elastin, and glycosaminoglycan synthesis by fibroblasts; activation of MMP remodeling enzymes; promotion of angiogenesis via VEGF and FGF upregulation; anti-inflammatory activity via TNF-α and IL-1β reduction; antioxidant effects via SOD induction; and gene regulation — research shows modulation of over 4,000 genes.

Skin rejuvenation: Multiple in vitro and clinical studies demonstrating collagen synthesis stimulation, wrinkle reduction, and improved skin density.

Wound healing: Accelerated wound closure and reduced scar tissue in both surgical and chronic wound models.

Hair research: Stimulation of follicle proliferation and size in mouse models; effects compared to pharmaceutical agents in some studies.

Gene expression reset: Landes et al. showed GHK-Cu reverses gene expression signature of aged human fibroblasts toward a younger phenotype.

Broad anti-inflammatory: Downregulates TNF-α, IL-1β, IL-6, and other pro-inflammatory cytokines in tissue models.