Hexarelin Acetate

Hexarelin is a synthetic hexapeptide GHRP with high selectivity for the ghrelin receptor (GHS-R1a). It stimulates pulsatile GH secretion from the anterior pituitary by directly activating GHS-R1a on somatotroph cells, suppressing somatostatin release from the hypothalamus, and synergizing with GHRH to amplify GH pulse magnitude. Uniquely among GHRPs, hexarelin also binds the CD36 scavenger receptor, suggesting direct cardiac and anti-fibrotic effects independent of the GH axis.

GH secretion: Among the most potent GHRPs tested in multiple species; well-characterized dose-dependent GH release kinetics.

Cardiac protection: CD36-mediated direct cardioprotective effects observed in ischemia-reperfusion animal models.

Anti-fibrotic: Reduced TGF-β and collagen deposition markers in heart failure models via CD36 pathway.

Desensitization: Continuous dosing leads to GHS-R1a downregulation; pulsatile protocols studied to maintain sensitivity.

Combination: Synergistic with CJC-1295 or Mod GRF 1-29 for amplified, physiologically-timed GH pulses.